Correlation between functional capacity and oxidative stress and inflammation in hemodialysis patients

AbstractIntroduction Patients with chronic kidney disease (CKD) may present impaired functional capacity due to peripheral muscle involvement. Oxidative stress and inflammation are probably involved in this pathophysiology. This study aimed evaluate the association between biomarkers of oxidative as well patients under hemodialysis therapy. Method Cross-sectional including 41 from a single center. Functional was assessed through 6-min walk test (6MWT). The blood were: malondialdehyde (MDA) (oxidative stress, TBARS method) angiopoietin-2 (Ang-2) (inflammation, ELISA). influence gender on impairment further explored. Results There an inversely proportional correlation 6MWD MDA (r = -,322 p 0.040) Ang-2 -, 376 0.016) values. 370.9 ± 101.2 m 391.4 108.2 women men, respectively (p < 0.001), which means 29.3% 34.3% reduction expected values for healthy individuals same age range. Conclusion CKD hemodialysis, regardless gender, presented performance 6MWT associated inflammation.